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KMID : 0358420090520060631
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 6 p.631 ~ p.635
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Declining concentrations of dehydroepiandrosterone sulfate and free testosterone with advancing age
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Han Myoung-Seok
Choi Il-Jung
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Abstract
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Objective: To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) or free testosterone (FT) levels and aging.
Methods: One hundred and thirty one women without androgen excess symptoms such as oligomenorrhea or amenorrhea or hirsutism were recruited for measuring serum DHEAS, FT levels by radioimmunoassay. A P-value <0.05 was considered to be significant statistically.
Results: The levels of DHEAS were 211.39±33.01 μg/dL (twenties, n=10), 127.99±11.79 μg/dL (thirties, n=31), 94.30±7.49 μg/dL (forties, n=57) and 71.79±5.71 μg/dL (over fifties, n=33) respectively (mean±SE, P<0.001). The levels of FT were 3.98±0.94 pg/ml (twenties, n=10), 3.37±0.47 pg/mL (thirties, n=31), 2.68±0.30 pg/mL (forties, n=57) and 1.97±0.28 pg/mL (fifties, n=33) respectively (mean±SE, P=0.030). Mean value declining of DHEAS (r=-0.48865, P<0.0001) was bigger than those of FT (r=-0.29334, P<0.0007).
Conclusion: Both DHEAS and FT levels decline with age and DHEAS decreases more steeply than FT.
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KEYWORD
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Dehydroepiandrosterone sulfate, Testosterone, Aging
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